{"ATC Code":["N - Nervous system","N01 - Anesthetics","N01A - Anesthetics, general","N01AB - Halogenated hydrocarbons","N01AB07","N01AB07 - Desflurane","QN - Nervous system","QN01 - Anesthetics","QN01A - Anesthetics, general","QN01AB - Halogenated hydrocarbons","QN01AB07 - Desflurane"],"Absorption, Distribution and Excretion":"Data regarding the Cmax, Tmax, and AUC of desflurane are not readily available.","Adverse Effects":"Desflurane, along with the other inhalational agents, sevoflurane and isoflurane, is a potent vasodilator and can cause a decrease in blood pressure by decreasing systemic vascular resistance. A concomitant increase in heart rate sometimes occurs. Cardiac output is typically preserved with the use of this agent. Desflurane dilates cerebral arteries and decreases the cerebral metabolic rate.","Aliases":["Suprane","Desflurano","difluoromethyl 1,2,2,2-tetrafluoroethyl ether","Desfluranum","I-653","I 653","2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether","1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane","Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-","CHEBI:4445","Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-, (+-)-","I653","Dtxcid30814874","N01AB07","Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-,(+-)-","688-023-8","1,2,2,2-Tetrafluoroethyl difluoromethyl ether","Mfcd00236716","2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether","Desfluran-O","HSDB 8058","Chf2ochfcf3","Schembl62917","Ethane,2-(difluoromethoxy)-1,1,1,2-tetrafluoro-","GTPL7156","orb2566499","1H,3H-Perfluoro(2-oxabutane)","Chembl1200733","Gtqdypawjdialy-uhfffaoysa-n","MSK16915_C","MSK169195","SBB088129","Akos006228397","DB01189","DB-053001","NS00014329","C07519","D00546","T86184","1-(difluoromethoxy)-1,2,2,2-tetrafluoroethane","En300-7635854","(2RS)-2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane","Desflurane; (2RS)-2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane; 2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane; Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-, (+/-)- (USP);"],"Biological Half-Life":"Desflurane has a terminal elimination half life of 8.16 ± 3.15 minutes.","Boiling Point":"23.5 °C","CAS":"57041-67-5","ChemicalClasses":["ether"],"Chirality":"racemic","Color/Form":"Liquid","DTXSID":"80866606","Density":"1.44 g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Classes":["Breast Feeding","Lactation","Anesthetics, Inhalation"],"Drug Indication":"Desflurane is indicated for the induction and maintenance of anesthesia in adults, as well as the maintenance of anesthesia in pediatric patients.","Drug Warnings":"Anesthetics, Inhalation","EliminationHalfLife":"Elimination dependent on minute ventilation","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"688-023-8","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":23,"Value":{"StringWithMarkup":[{"String":"CRS35BZ94Q"}]}},{"Name":"Active Moiety","ReferenceNumber":23,"Value":{"StringWithMarkup":[{"String":"DESFLURANE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":23,"Value":{"StringWithMarkup":[{"String":"Physiologic Effects [PE] - General Anesthesia"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":23,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - General Anesthetic"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":23,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-42113","Length":10,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Desflurane"},{"Extra":"CID-42113","Length":10,"Start":62,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/desflurane"}],"String":"Desflurane is a General Anesthetic. The physiologic effect of desflurane is by means of General Anesthesia."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":33,"Value":{"StringWithMarkup":[{"String":"DESFLURANE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":33,"Value":{"StringWithMarkup":[{"String":"General Anesthesia [PE]; General Anesthetic [EPC]"}]}}],"Formating":[],"HMDB ID":"HMDB0015320","Health Effects":"It may cause tachycardia and airway irritability when administered at concentrations greater than 10 vol%. [Wikipedia]","HeavyAtomCount":10,"Human Drugs":"Breast Feeding; Lactation; Anesthetics, Inhalation","IUPACName":"2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane","InChI":"InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H","InChIKey":"DPYMFVXJLLWWEU-UHFFFAOYSA-N","Interactions":"Anesthetic concentrations of desflurane at equilibrium (administered for 15 or more minutes before testing) reduced the ED95 of succinylcholine by approximately 30% and that of atracurium and pancuronium by approximately 50% compared to N2O/opioid anesthesia. The effect of desflurane on duration of nondepolarizing neuromuscular blockade has not been studied.","MeSH Headers":[{"Id":"M0151698","Link":"https://id.nlm.nih.gov/mesh/M0151698.html","Name":"Desflurane","Ref":58},{"Id":"M0151699","Link":"https://id.nlm.nih.gov/mesh/M0151699.html","Name":"I 653","Ref":60},{"Id":"M0477592","Link":"https://id.nlm.nih.gov/mesh/M0477592.html","Name":"Suprane","Ref":61},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":62},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":85},{"Id":"M0027998","Link":"https://id.nlm.nih.gov/mesh/M0027998.html","Name":"Anesthetics, Inhalation","Ref":86}],"MeSH Pharmacological Classification":[{"Id":"M0027998","Link":"https://id.nlm.nih.gov/mesh/M0027998.html","Name":"Anesthetics, Inhalation","Ref":86}],"Mechanism of Action":"The mechanism of inhalational anesthetics is still not fully understood. They can block excitatory ion channels and increase the activity of inhibitory ion channels. The most notable agonism is at the GABA\u003csub\u003eA\u003c/sub\u003e channel. Desflurane is also an agonist of glycine receptors, antagonist of glutamate receptors, inducer of potassium voltage gated channels, and inhibits both NADH-ubiquinone oxioreductase chain 1 and calcium transporting ATPases.  An older school of thought is the unitary theory of general anesthetic action, suggesting that desflurane affects the lipid bilayer of cells. Studies of other halogenated inhalational anesthetics have shown that the lipid bilayer spreads out more thinly as the anesthetic incorporates into the bilayer. However, the anesthetic does not bind to lipid heads or acyl chains of hydrocarbons in the bilayer. The effect of incorporating into the lipid bilayer is not well described. By incorporating into the lipid bilayer, anesthetics may introduce disorder in the lipids, leading to some indirect effect on ion channels. However, this theory remains controversial.","Metabolism/Metabolites":"Desflurane is minimally defluorinated by CYP2E1, to the extent that serum fluoride levels do not increase above baseline levels.","MolecularFormula":"C\u003csub\u003e3\u003c/sub\u003eH\u003csub\u003e2\u003c/sub\u003eF\u003csub\u003e6\u003c/sub\u003eO","MolecularWeight":"168.04 g/mol","Odor":"Slight non-pungent odor","Opticalactivity":"( + / - )","Pharmacodynamics":"Desflurane is a general inhalation anesthetic. It has a short duration of action as it is rapidly cleared. Patients should be counselled regarding the risks of malignant hyperthermia, perioperative hyperkalemia, respiratory adverse reactions in pediatric patients, QTc prolongation, hepatobiliary disorders, pediatric neurotoxicity, and postoperative agitation in children.","Physical Description":"Liquid","PubChemId":42113,"PubChemTitle":"Desflurane","Record Description":["LiverTox|CNS|Anesthetic|Halogenated, volatile"],"Records":{"UNII":{"Impurities":["chloroform","1,1,2-trichlorotrifluoroethane","bis-(1,2,2,2-tetrafluoroethyl)ether","isoflurane","methylene chloride","trichloromonofluoromethane","acetone","dichlorofluoromethane"]}},"Reddit Experience Reports":[],"RefChem":"56506","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Desflurane","Name":"Desflurane","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q419383","Name":"Desflurane","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01189","Name":"Desflurane","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/42113","Name":"Desflurane","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57041-67-5","Name":"Desflurane","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015320","Name":"Desflurane","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07519","Name":"Desflurane","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/CRS35BZ94Q","Name":"Desflurane","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID80866606","Name":"Desflurane","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 42113, Desflurane. Accessed August 24, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/42113\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/42113\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Desflurane. UNII: CRS35BZ94Q. Global Substance Registration System. Accessed August 24, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/CRS35BZ94Q\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/CRS35BZ94Q\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed August 24, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"C(C(F)(F)F)(OC(F)F)F","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S4 substance"},{"gov":"Brazil","ref":["3"],"schedule":"C1 substance"},{"gov":"United States","ref":[],"schedule":"prescription only substance"}],"Solubility":"Negligible","StereoisomerData":[{"ChemicalClasses":["ether"],"SMILES":"FC(F)O[C@H](F)C(F)(F)F","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 69.986 42.179\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" 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SUPRANE (desflurane, USP) is not recommended for induction of anesthesia in pediatric patients because of a high incidence of moderate to severe upper airway adverse events (see WARNINGS). After induction of anesthesia with agents other than SUPRANE, and tracheal intubation, SUPRANE is indicated for maintenance of anesthesia in infants and children. /Included in US product label/","Title":"Desflurane","Toxicity Data":"LD50: 312.0 mg.kg-1 (i.v,swiss rate) (A698)","Treatment":"In the event of overdosage, or suspected overdosage, take the following actions: discontinue administration of Desflurane, maintain a patent airway, initiate assisted or controlled ventilation with  oxygen, and maintain adequate cardiovascular function. (L1712)","UNII":"CRS35BZ94Q","Wikidata":"Q419383","Wikipedia":"Desflurane","XLogP":2.6}