{"ATC Code":["M - Musculo-skeletal system","M01 - Antiinflammatory and antirheumatic products","M01A - Antiinflammatory and antirheumatic products, non-steroids","M01AE - Propionic acid derivatives","M01AE14 - Dexibuprofen","QM - Musculo-skeletal system","QM01 - Antiinflammatory and antirheumatic products","QM01A - Antiinflammatory and antirheumatic products, non-steroids","QM01AE - Propionic acid derivatives","QM01AE14 - Dexibuprofen"],"Absorption, Distribution and Excretion":"The time it take to reach peak plasma concentration is 2.25-5 hours post-administration of oral tablets containing 300mg of dexibuprofen. For more information, refer to [ibuprofen].","Aliases":["Dexibuprofene","Dexibuprofeno","Seractil","Ibuproten","p-Isobutylhydratropic acid","Dexibuprofenum","s-ibuprofen","(2S)-2-(4-isobutylphenyl)propanoic acid","Ibuprofen","NSC-759814","α-methyl-4-(2-methylpropyl)benzeneacetic acid","Dtxcid6028650","Chebi:43415","Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (S)-","(2S)-2-(4-(2-methylpropyl)phenyl)propanoic acid","M01AE14","(+)-Ibuprofen","S(+)-Ibuprofen","2-(4-Isobutylphenyl)propanoic acid","(+)-2-(4-Isobutylphenyl)propionic acid","S-(+)-ibuprofen","Mfcd00069289","(+)-4-Isobutyl-α-methylphenylacetic acid","CHEMBL175","2-(4-Isobutylphenyl)propionic acid","Ncgc00016861-05","2-(4-isobutyl-phenyl)-propionic acid","Cas-51146-56-6","S-(+)-2-(4-Isobutylphenyl)propionic acid","(s)-(+)-4-isobutyl-a-methylphenylacetic acid","Smr000326688","Atriscal","Dolomin","DexOptifen","Maxibufen Syr","Maxibufen ER","ibuprofen-(S)","Ibuprophen","(s)(+)ibuprofen","S (+) Ibuprofen","(s)(+) ibuprofen","2-(p-Isobutylphenyl)propionic acid","Lopac-I-106","Prestwick0_000907","Prestwick1_000907","Prestwick2_000907","Prestwick3_000907","Lopac-I-4883","Lopac0_000654","Schembl43531","BSPBio_000754","Mls001066327","Mls001335879","Mls001335880","SPBio_002953","BPBio1_000830","orb1224869","orb1310605","Schembl30091137","HMS1570F16","HMS2097F16","HMS2231C07","HMS3262C09","HMS3714F16","HY-78131AR","Pharmakon1600-01502363","Tox21_113141","Tox21_500654","Bdbm50169047","EBC-04181","HY-78131A","NSC759814","Akos015890528","Akos015994628","CCG-204740","CS-1393","DB09213","FI24528","HS-0088","LP00654","Msk156869-100m","NSC 759814","Sdccgsbi-0050633.p002","Ncgc00015529-01","Ncgc00015529-02","Ncgc00015529-03","Ncgc00015529-11","Ncgc00016861-01","Ncgc00016861-02","Ncgc00016861-03","Ncgc00016861-06","Ncgc00016861-13","Ncgc00094017-01","Ncgc00094017-02","Ncgc00094017-04","Ncgc00261339-01","SY046826","Unm-0000306099","AB00513957","EU-0100654","I-106","I0549","NS00098758","T0448","(+)-Ibuprofen, ReagentPlus(R), 99%","(s)-(+)-2-(4-isobutylphenyl) propionic acid","D03715","En300-180104","O10202","Ab00513957_07","F079519","Sr-01000075945","Sr-01000761395","(2S)-2-[4-(2-Methylpropyl)phenyl]propionic acid","Sr-01000075945-1","Sr-01000761395-2","(+)-Ibuprofen Solution in Methanol, 100ug/mL","Brd-k14965640-001-03-3","Brd-k14965640-001-12-4","α-Methyl-4-(2-methylpropyl)benzeneacetic acid","Z1508914616","(αS)-α-Methyl-4-(2-methylpropyl)benzeneacetic acid","benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αS)-","Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-,(αS)-","Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (s)-","Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αS)-"],"Biological Half-Life":"Oral tablets containing 300mg of dexibuprofen results in 2.2-4.7 hours. For more information, refer to [ibuprofen].","CAS":"51146-56-6","ChemicalClasses":[],"Chirality":"absolute","Classes":["Nonsteroidal anti-inflammatory drug"],"DBI-IGS":["Dexibuprofen","Ibuprofen"],"DTXSID":"9048724","Dosing Info":[{"Method":"Oral","Tiers":{"Common":{"Entries":16,"Lower":277.8,"Percentage":66.7,"Unit":"mg","Upper":400},"Extreme":{"Entries":0,"Lower":400,"Percentage":0,"Unit":"mg","Upper":400},"Heavy":{"Entries":0,"Lower":400,"Percentage":0,"Unit":"mg","Upper":400},"Light":{"Entries":8,"Lower":277.8,"Percentage":33.3,"Unit":"mg","Upper":277.8},"Strong":{"Entries":0,"Lower":400,"Percentage":0,"Unit":"mg","Upper":400}}}],"Drug Indication":"For more information, refer to [ibuprofen].","EliminationHalfLife":"","Esters":[],"European Community (EC) Number":"610-620-9","Formating":[],"HeavyAtomCount":15,"IUPACName":"(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid","InChI":"InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1","InChIKey":"HEFNNWSXXWATRW-JTQLQIEISA-N","MeSH Headers":[{"Id":"M0534105","Link":"https://id.nlm.nih.gov/mesh/M0534105.html","Name":"dexibuprofen","Ref":79},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":81},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":100}],"Mechanism of Action":"Like common NSAIDs, dexibuprofen is an active enantiomer of [ibuprofen] that suppresses the prostanoid synthesis in the inflammatory cells via inhibition of the COX-2 isoform of the arachidonic acid COX. For more information, refer to [ibuprofen].","Melting Point":"49-53","Metabolism/Metabolites":"For more information, refer to [ibuprofen].","MolecularFormula":"C\u003csub\u003e13\u003c/sub\u003eH\u003csub\u003e18\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"206.28 g/mol","Opticalactivity":"( + )","Pharmacodynamics":"For more information, refer to [ibuprofen].","PubChemId":39912,"PubChemTitle":"Dexibuprofen","Records":{"UNII":{"Impurities":["2-(3-isobutylphenyl)propionic acid, (s)-"]}},"RefChem":"585862","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Dexibuprofen","Name":"Dexibuprofen","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q420051","Name":"Dexibuprofen","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB09213","Name":"Dexibuprofen","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/39912","Name":"Dexibuprofen","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=51146-56-6","Name":"Dexibuprofen","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D03715","Name":"Dexibuprofen","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/671DKG7P5S","Name":"Dexibuprofen","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9048724","Name":"Dexibuprofen","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 39912, Dexibuprofen. Accessed August 10, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/39912\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/39912\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Dexibuprofen. UNII: 671DKG7P5S. Global Substance Registration System. Accessed August 10, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/671DKG7P5S\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/671DKG7P5S\u003c/a\u003e"],"SMILES":"C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O","SaltData":[],"Salts":[],"Scheduling":[],"Solubility":"Insoluble","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 113.964 47.395\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h114v48H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"M33.251 15.8h.8L36.053.561h-4.8z\" class=\"bond\"/\u003e\u003cpath d=\"m33.651 15.8 13.197 7.622\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m60.056 15.802-13.208 7.62M60.056 18.618l-10.77 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"m60.056 15.802 13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M73.264 38.662v-15.24M70.825 37.254V24.831\"/\u003e\u003c/g\u003e\u003cpath d=\"m73.264 38.662-13.208 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m46.848 38.662 13.208 7.62M49.286 37.254l10.77 6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M46.848 23.422v15.24M73.264 38.662l13.197 7.623M86.461 46.285l13.199-7.618M99.66 38.667l13.197 7.622M99.66 38.667l.003-15.24M33.651 15.8l-13.2 7.618\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m21.671 22.715-.002 11.751M19.232 22.714l-.002 11.751\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m21.669 34.466.001-5.876M19.23 34.465l.001-5.875\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.451 23.418-9.589-5.538\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M20.452 36.613q-.738 0-1.173.554-.429.548-.429 1.494 0 .947.429 1.494.435.548 1.173.548t1.167-.548q.428-.547.428-1.494 0-.946-.428-1.494-.429-.554-1.167-.554m0-.547q1.054 0 1.679.708.631.703.631 1.887 0 1.179-.631 1.887-.625.703-1.679.703t-1.685-.703q-.631-.702-.631-1.887 0-1.184.631-1.887.631-.708 1.685-.708\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M7.257 13.751q-.738 0-1.173.554-.428.548-.428 1.494 0 .947.428 1.494.435.548 1.173.548t1.167-.548q.429-.547.429-1.494 0-.946-.429-1.494-.429-.554-1.167-.554m0-.547q1.054 0 1.679.708.631.702.631 1.887 0 1.179-.631 1.887-.625.703-1.679.703-1.053 0-1.684-.703-.632-.702-.632-1.887t.632-1.887q.631-.708 1.684-.708M.56 13.293h.679v2.048h2.458v-2.048h.673v5h-.673v-2.381H1.239v2.381H.56z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m10.862 17.88 4.795 2.769\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Dexibuprofen","UNII":"671DKG7P5S","Wikidata":"Q420051","Wikipedia":"Dexibuprofen","XLogP":3.5}