{"Adverse Effects":"Neurotoxin - Acute solvent syndrome","Aliases":["2,2,2-Trifluoroethyl vinyl ether","Fluoromar","Ethene, (2,2,2-trifluoroethoxy)-","Flurossene","NSC-760364","fluoroxene","2,2,2-Trifluoroethoxyethene","206-977-1","(2,2,2-Trifluoroethoxy)ethene","Fluroxeno","Mfcd00864407","Fluroxenum","Einecs 206-977-1","Brn 1745876","Ether, 2,2,2-trifluoroethyl vinyl","Schembl60167","Chembl141446","Chebi:134757","HMS3264D10","Pharmakon1600-01506162","2,2,2-trifluoro-1-vinyloxyethane","HY-B1163","NSC760364","SBB085620","Akos009159362","CCG-213622","CS-4763","NSC 760364","2,2,2-Trifluoroethyl vinyl ether, 97%","DA-73411","(2,2,2-Trifluoroethoxy)ethylene, Fluroxene","NS00043206","D04237","Ab01563344_01","Sr-01000944223","Sr-01000944223-1","Brd-k56908511-001-01-2"],"Associated Disorders and Diseases":"Solvents, acute toxic effect [Category: Acute Poisoning]","Boiling Point":"109 °","CAS":"406-90-6","Chemical Classes":"Other Uses -\u003e Waste Anesthetic Gases","ChemicalClasses":["ether"],"Chirality":"achiral","DTXSID":"5059957","Density":"1.14 (NIOSH, 2024) - Denser than water; will sink g/cm\u003csup\u003e3\u003c/sup\u003e","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"206-977-1","Formating":[],"HMDB ID":"HMDB0252413","HeavyAtomCount":8,"IUPACName":"2-ethenoxy-1,1,1-trifluoroethane","InChI":"InChI=1S/C4H5F3O/c1-2-8-3-4(5,6)7/h2H,1,3H2","InChIKey":"DLEGDLSLRSOURQ-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0224679","Link":"https://id.nlm.nih.gov/mesh/M0224679.html","Name":"fluroxene","Ref":33},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":35},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":53}],"MolecularFormula":"C\u003csub\u003e4\u003c/sub\u003eH\u003csub\u003e5\u003c/sub\u003eF\u003csub\u003e3\u003c/sub\u003eO","MolecularWeight":"126.08 g/mol","Physical Description":"Volatile Liquid. Bp: 43 °C. Density: 1.14 g cm-3. Formerly used as an inhalation anesthetic.","PubChemId":9844,"PubChemTitle":"Fluroxene","Records":{"UNII":{"Impurities":[]}},"Reddit Experience Reports":[],"RefChem":"599468","RefCount":9,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Fluroxene","Name":"Fluroxene","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q14850809","Name":"Fluroxene","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB20681","Name":"Fluroxene","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/9844","Name":"Fluroxene","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=406-90-6","Name":"Fluroxene","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0252413","Name":"Fluroxene","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D04237","Name":"Fluroxene","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/FO7JHA3G03","Name":"Fluroxene","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID5059957","Name":"Fluroxene","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 9844, Fluroxene. Accessed August 24, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/9844\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/9844\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fluroxene. UNII: FO7JHA3G03. Global Substance Registration System. Accessed August 24, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/FO7JHA3G03\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/FO7JHA3G03\u003c/a\u003e","Stoelting RK, Hillier SC. Pharmacology and Physiology in Anesthetic Practice. Lippincott Williams \u0026 Wilkins. January 11, 2012.","Jakob AK, Kopp SL, Bacon DR, Smith HM. Clinical Anesthesia. Lippincott Williams \u0026 Wilkins. January 1, 2011.","Lichtiger M, Moya F. Introduction to the practice of anesthesia. Medical Dept., Harper \u0026 Row. January 1, 1978. Accessed August 24, 2026. \u003ca href=https://books.google.com/books?id=ecZpAAAAMAAJ\u003ehttps://books.google.com/books?id=ecZpAAAAMAAJ\u003c/a\u003e","Acta anaesthesiologica Belgica. Acta Medica Belgica }. Accessed August 24, 2026. \u003ca href=https://books.google.com/books?id=KmsxAAAAIAAJ\u003ehttps://books.google.com/books?id=KmsxAAAAIAAJ\u003c/a\u003e","Fiserova-Bergerova V. Metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether. Environmental Health Perspectives. December 1, 1977; 21:225–230.","Kaminsky LS, Fraser JM. Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol. Critical Reviews in Toxicology. 19(2):87–112."],"SMILES":"C=COCC(F)(F)F","SaltData":[],"Salts":[],"Scheduling":[{"gov":"United States","ref":["3","4","5","6","7","8"],"schedule":"}-}\n\n'''Fluroxene''' (International Nonproprietary Name|INN, United States Adopted Name|USAN; brand name '''Fluoromar'''), or '''2,2,2-trifluoroethyl vinyl ether''', is a Inhalational anesthetic#Volatile anesthetic|volatile, inhalational anesthetic. It was synthesized in 1951, and was introduced for clinical use in 1954, but was voluntarily withdrawn from the market in 1974 due to its potential flammability and accumulating evidence that it could cause organ (biology)|organ toxicity. In any case, prior to being discontinued, it had largely been superseded by halothane. Fluroxene is metabolized to 2,2,2-trifluoroethanol, a compound responsible for some of the toxicity seen with fluroxene use.\n\n== See also ==\n* Divinyl ether\n* Thiomethoxyflurane\n\n== References ==\n{-{Reflist|2}-}\n\n{-{General anesthetics}-}\n{-{GABAAR PAMs}-}\n\nCategory:General anesthetics\nCategory:GABAA receptor positive allosteric modulators\nCategory:Trifluoroethyl compounds\nCategory:Vinyl ethers\n\n{-{nervous-system-drug-stub}-} substance"}],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 69.095 32.517\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#90e050\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h70v33H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m54.791 8.639 13.198 7.62M54.791 11.454 66.77 18.37\"/\u003e\u003c/g\u003e\u003cpath d=\"m54.791 8.639-9.59 5.536M37.984 14.175l-9.59-5.536M28.394 8.639l-13.198 7.62M15.196 16.259 8.916 5.382M15.196 16.259l-10.498 6.06M15.196 16.259l5.382 9.322\" class=\"bond\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M41.595 14.214q-.738 0-1.172.553-.429.548-.429 1.495 0 .946.429 1.494.434.547 1.172.547.739 0 1.167-.547.429-.548.429-1.494 0-.947-.429-1.495-.428-.553-1.167-.553m0-.548q1.054 0 1.679.708.631.703.631 1.888 0 1.178-.631 1.887-.625.702-1.679.702-1.053 0-1.684-.702-.631-.703-.631-1.887t.631-1.888q.631-.708 1.684-.708\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M6.138.56h2.876v.571H6.817v1.471h1.982v.571H6.817v2.388h-.679zM.56 21.378h2.875v.572H1.239v1.47h1.982v.572H1.239v2.387H.56zM21.378 26.956h2.876v.572h-2.197v1.47h1.982v.572h-1.982v2.387h-.679z\" class=\"atom\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m45.201 14.175 4.795-2.768M37.984 14.175l-4.795-2.768\" class=\"hi\"/\u003e\u003cpath stroke=\"#90e050\" d=\"m8.916 5.382 3.14 5.438M4.698 22.319l5.249-3.03M20.578 25.581l-2.691-4.661\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Fluroxene","UNII":"FO7JHA3G03","Wikidata":"Q14850809","Wikipedia":"Fluroxene","XLogP":1.9}