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Daridorexant

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Daridorexant
Daridorexant
[]
Daridorexant hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
[]
Conformer structure via 3Dmol.js
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Physical properties
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450.9 g/mol [1]
4.1 [1]
Structural Identifiers
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C23H23ClN6O2 [1]
[(2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone [1]
CC1=C(C=CC2=C1N=C(N2)[C@@]3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl [1]
InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1 [1]
InChIKeyNBGABHGMJVIVBW-QHCPKHFHSA-N [1]
Pharmacokinetics[]
Elimination half-life8 hours (6 – 10 hours)[6]
Duration of action~8 hours (50 mg)

Daridorexant (also known as Nemorexant, ACT-541468, Quviviq, Dea no. 2410, Methanone, ((2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)-, daridorexantum, ((2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl)-(5-methoxy-2-(triazol-2-yl)phenyl)methanone, Dtxcid901766549, ((S)-(2-(5-chloro-4-methyl-1H-benzo(d)imidazol-2-yl)-2-methylpyrrolidin-1-yl) (5 methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone) or 5-chloro-2-((2S)-1-(5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoyl)-2-methylpyrrolidin-2-yl)-4-methyl-1H-1,3-benzodiazole) is a substance of the benzylamine class.

Chemistry

Salts []

Daridorexant is typically found in the form of its hydrochloride salt.

 []

Daridorexant is a absolute mixture.

Pharmacology

In the () daridorexant acts as a daridorexant (), hypnotics and sedative (), orexin receptor antagonist () and psycholeptic ().[1]

Subjective effects []

emily / Daridorexant []
Routes:
  • Oral (50mg)
Indication:Notes:
  • uncertain activity but worth a try since the long term adverse effects seem to be a lot more tolerable compared to other sleeping medication
Pilz / Daridorexant []
Routes:
  • Oral (50mg)
Salts:
  • Hydrochloride
Source:
  • Quviviq 50mg tablet
Effects:Notes:
  • no major effects noted; still worth a try for insomnia

 []

  • Canada: Daridorexant is a prescription only substance.[3][4]
  • United Kingdom: Daridorexant is a prescription only substance.[5]
  • United States: Daridorexant is a Schedule I under the "Controlled Substances Act (CSA)".
  • European Union: Daridorexant is a prescription only substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 91801202, Daridorexant. Accessed August 10, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/91801202

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Daridorexant. UNII: LMQ24G57E9. Global Substance Registration System. Accessed August 10, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/LMQ24G57E9

  3. Summary Basis of Decision for Quviviq. August 4, 2023. Accessed August 10, 2026. https://dhpp.hpfb-dgpsa.ca/review-documents/resource/SBD1691500592141

  4. Details for: Quviviq. September 8, 2023. Accessed August 10, 2026. https://dhpp.hpfb-dgpsa.ca/dhpp/resource/102615

  5. Daridorexant Medicinal forms. The National Institute for Health and Care Excellence (NICE). Accessed August 10, 2026. https://bnf.nice.org.uk/drugs/daridorexant/medicinal-forms/

  6. Muehlan C, Vaillant C, Zenklusen I, Kraehenbuehl S, Dingemanse J. Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders. Expert Opinion on Drug Metabolism & Toxicology. November 1, 2020; 16(11):1063–1078.