Methoxyflurane

Methoxyflurane

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	164.96 g/mol ^[1]
Density	1.426 at 68 °F (NTP, 1992) - Denser than water; will sink g/cm³ ^[1]
Appearance	Liquid ^[1]
Odor	Fruity ^[1]
Melting point	-31 °F (NTP, 1992) ^[1]
Boiling point	220.3 ° ^[1]
Solubility	less than 1 mg/mL at 66 °F (NTP, 1992) ^[1]
Predicted LogP	2.2 ^[1]

Structural Identifiers []
Molecular formula	C₃H₄Cl₂F₂O ^[1]
IUPAC name	2,2-dichloro-1,1-difluoro-1-methoxyethane ^[1]
SMILES	COC(C(Cl)Cl)(F)F ^[1]
InChI	InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3 ^[1]
InChIKey	RFKMCNOHBTXSMU-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Duration of action	Typically up - 30 – 60 minutes depending on the frequency of breaths

Methoxyflurane (also known as Methoxyfluran, Penthrane, Methoflurane, Anecotan, 2,2-Dichloro-1,1-difluoroethyl methyl ether, Metoxfluran, Metoxifluran, Analgizer, Inhalan or Metofane) is a substance of the ether class.

Chemistry

Stereochemistry []

Methoxyflurane is a achiral mixture.

Pharmacology

ATC Classification

In the nervous system (N) methoxyflurane acts as a analgesic (N02), methoxyflurane (N02BG09), other analgesics and antipyretic (N02B) and other analgesics and antipyretic (N02BG).^[1]

Legal status []

Australia: Methoxyflurane is a S4 substance.^[3]^[4]
Brazil: Methoxyflurane is a C1 substance.
Canada: Methoxyflurane is a prescription only substance.
United Kingdom: Methoxyflurane is a prescription only substance.
European Union: Methoxyflurane is a prescription only substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 4116, Methoxyflurane. Accessed August 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/4116
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Methoxyflurane. UNII: 30905R8O7B. Global Substance Registration System. Accessed August 24, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/30905R8O7B
Penthrox methoxyflurane inhalation bottle (43144). August 12, 2022. Accessed August 24, 2026. https://www.tga.gov.au/resources/artg/43144
Penthrox (311927). August 12, 2022. Accessed August 24, 2026. https://www.tga.gov.au/resources/artg/311927

AnodyneWiki