Ketanserin

R-41468, R41468, R-41,468, KJK-945, R-49945, R49945

Salts []
Ketanserin tartrate

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	395.4 g/mol ^[1]
Predicted LogP	2.6 ^[1]

Structural Identifiers []
Molecular formula	C₂₂H₂₂FN₃O₃ ^[1]
IUPAC name	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione ^[1]
SMILES	C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O ^[1]
InChI	InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29) ^[1]
InChIKey	FPCCSQOGAWCVBH-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	3.5 – 29 hours^[3]^[4]

Ketanserin (also known as Ketanserine, Ketanserina, Ketanserinum, Ketaserin, 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione, Serefrex, R-41468, R-41,468, R 41468 or R 41,468) is a substance of the benzylamine class.

Chemistry

Salts []

Ketanserin is typically found in the form of its tartrate salt.

Stereochemistry []

Ketanserin is a achiral mixture.

Pharmacology

ATC Classification

In the cardiovascular system (C) ketanserin acts

Subjective effects []

emily / Ketanserin []
Routes: Sublingual (15mg) Onset: 10 - 15 min Comeup: 20 - 25 min Duration: ? Notes: taken 30min after ingesting 2C-B. the psychedelic effects were completely gone ~40min after ingestion

emily / Ketanserin []

Routes:

Sublingual (15mg)
Onset: 10 - 15 min
Comeup: 20 - 25 min
Duration: ?

Notes:

taken 30min after ingesting 2C-B. the psychedelic effects were completely gone ~40min after ingestion

Pilz / Ketanserin []
Routes: Sublingual (20mg) Onset: ~ 20min Duration: ? Effects: Stops 2-CB trips No major side-effects

Pilz / Ketanserin []

Routes:

Sublingual (20mg)
Onset: ~ 20min
Duration: ?

Effects:

Stops 2-CB trips
No major side-effects

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 3822, Ketanserin. Accessed August 10, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3822
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Ketanserin. UNII: 97F9DE4CT4. Global Substance Registration System. Accessed August 10, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/97F9DE4CT4
Cold GE, Dahl BL. Topics in Neuroanaesthesia and Neurointensive Care: Experimental and Clinical Studies upon Cerebral Circulation, Metabolism and Intracranial Pressure. Springer Science & Business Media. November 11, 2013. Accessed August 10, 2026. https://books.google.com/books?id=cYnqCAAAQBAJ&pg=PA193}
Antihypertensive Drugs Today. VSP. 1992. Accessed August 10, 2026. https://books.google.com/books?id=PghVgVDfF7UC&pg=PA191}

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