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Ketanserin

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R-41468, R41468, R-41,468, KJK-945, R-49945, R49945
Ketanserin
[]
Ketanserin tartrate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
[]
Conformer structure via 3Dmol.js
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Physical properties
[]
395.4 g/mol [1]
2.6 [1]
Structural Identifiers
[]
C22H22FN3O3 [1]
3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione [1]
C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O [1]
InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29) [1]
InChIKeyFPCCSQOGAWCVBH-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life3.5 – 29 hours[3][4]

Ketanserin (also known as Ketanserine, Ketanserina, Ketanserinum, Ketaserin, 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione, Serefrex, R-41468, R-41,468, R 41468 or R 41,468) is a substance of the benzylamine class.

Chemistry

Salts []

Ketanserin is typically found in the form of its tartrate salt.

 []

Ketanserin is a achiral mixture.

Pharmacology

In the () ketanserin acts

Subjective effects []

emily / Ketanserin []
Routes:
  • Sublingual (15mg)
    Onset: 10 - 15 min
    Comeup: 20 - 25 min
    Duration: ?
Notes:
  • taken 30min after ingesting 2C-B. the psychedelic effects were completely gone ~40min after ingestion
Pilz / Ketanserin []
Routes:
  • Sublingual (20mg)
    Onset: ~ 20min
    Duration: ?
Effects:
  • Stops 2-CB trips
  • No major side-effects

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3822, Ketanserin. Accessed August 10, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3822

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Ketanserin. UNII: 97F9DE4CT4. Global Substance Registration System. Accessed August 10, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/97F9DE4CT4

  3. Cold GE, Dahl BL. Topics in Neuroanaesthesia and Neurointensive Care: Experimental and Clinical Studies upon Cerebral Circulation, Metabolism and Intracranial Pressure. Springer Science & Business Media. November 11, 2013. Accessed August 10, 2026. https://books.google.com/books?id=cYnqCAAAQBAJ&pg=PA193}

  4. Antihypertensive Drugs Today. VSP. 1992. Accessed August 10, 2026. https://books.google.com/books?id=PghVgVDfF7UC&pg=PA191}